According to the pipes’ vibration phenomenon of the vacuum hermetic closure system in ketone-benzol-dewaxing plant of No.2 Refinery in PetroChina Fushun Petrochemical Company，the researchers used the Bently velocity sensor and the rotatory state test and fault diagnosis CAMD-6100 to detect the vibration of pipelines in vacuum compressor J-6/3, then some important data and conclusions were obtained. It indicates that vibration of equilibrium pipe with more elbows is vigorous and the vibration of the pipe near motivation is much more vigorous. Through simplifying pipeline system, a dynamics pattern of equilibrium pipes was established. The software ANSYS was adopted to analyze system characteristic value, characteristic vector and vibration pattern. It is found that certain-order intrinsic frequency of pipelines is exactly near diploid frequency of motivation, which approves the deduction. In the premise of analyzing vibratory spectrums of pipes and vibration causes, improved measures were taken, such as changing space distribution of the pipelines, adding equipments of vibration reduction and altering system’s stiffness matrix, to alleviate vibration of pipelines. Service life of pipelines is prolonged and product safety is promoted.